N-Linked glycosylation profiles of therapeutic induced senescent (TIS) triple negative breast cancer cells (TNBC) and their extracellular vesicle (EV) progeny

Author:

Kavanagh Emma L.123,Halasz Melinda45623ORCID,Dowling Paul7893ORCID,Withers Jo101123,Lindsay Sinéad123,Higgins Michaela J.121323,Irwin Jane A.14623ORCID,Rudd Pauline M.101123,Saldova Radka1231011ORCID,McCann Amanda12345ORCID

Affiliation:

1. UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin (UCD)

2. Dublin

3. Ireland

4. UCD School of Medicine

5. College of Health and Agricultural Science (CHAS)

6. University College Dublin (UCD)

7. Biology Department

8. National University of Ireland (NUI) Maynooth, Co.

9. Kildare

10. The National Institute for Bioprocessing

11. Research and Training (NIBRT)

12. Oncology Department

13. Mater Misericordiae University Hospital (MMUH)

14. UCD School of Veterinary Medicine

Abstract

Therapeutic-induced-senescent (TIS) Cal51 TNBC cells display differential N-glycan moieties compared to non-senescent cells, depending on cellular location and EV progeny.

Funder

Science Foundation Ireland

University College Dublin

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

Reference64 articles.

1. Essentials of Glycobiology , ed. A. Varki , R. D. Cummings , J. D. Esko , H. H. Freeze , P. Stanley , C. R. Bertozzi , G. W. Hart and M. E. Etzler , Cold Spring Harbor Laboratory Press , Cold Spring Harbor (NY) , 2nd edn, 2009

2. A systematic approach to protein glycosylation analysis: a path through the maze

3. HPLC-based analysis of serum N-glycans on a 96-well plate platform with dedicated database software

4. Ultrahigh Throughput, Ultrafiltration-Based N-Glycomics Platform for Ultraperformance Liquid Chromatography (ULTRA3)

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