Mitochondria-targeting nanozyme alleviating temporomandibular joint pain by inhibiting the TNFα/NF-κB/NEAT1 pathway

Author:

Bai Qian1,Zhou Yaoyao1,Cui Xiaona12,Si Haichao3,Wu Tingting1,Nasir Abdul14,Ma Heng14,Xing Junyue5,Wang Yingying5,Cheng Xiaolei5,Liu Xiaojun2,Qi Shaoyan2,Li Zhisong4,Tang Hao5ORCID

Affiliation:

1. Medical Research Center, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China

2. Department of Critical Care Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

3. Department of Anesthesiology, Nanyang Central Hospital, Nanyang, Henan, China

4. Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

5. National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine, Heart Center of Henan Provincial People's Hospital, Central China Fuwai Hospital of Zhengzhou University, Fuwai Central China Cardiovascular Hospital & Central China Branch of National Center for Cardiovascular Diseases, Zhengzhou, Henan, 451464, China

Abstract

Mitochondria-targeting MOF-based nanozyme alleviating temporomandibular joint pain by inhibiting the TNFα/NF-κB/NEAT1 pathway based on oxidative stress regulation.

Funder

Natural Science Foundation of Henan Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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