Organocatalytic asymmetric cascade 1,6-addition/hemiketalization/retro-Henry reaction of ortho-hydroxyphenyl-substituted p-QMs with α-nitroketones-Reference-Cited by-同舟云学术

Organocatalytic asymmetric cascade 1,6-addition/hemiketalization/retro-Henry reaction of ortho-hydroxyphenyl-substituted p-QMs with α-nitroketones

Published:2020 Issue:14 Volume:18 Page:2641-2645
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhou Jing¹²³⁴⁵^ORCID,Bai Li-Juan¹²³⁴⁵,Liang Guo-Juan¹²³⁴⁵,Xu Qi-Gui¹²³⁴⁵,Zhou Li-Ping¹²³⁴⁵,Zhou Hui¹²³⁴⁵^ORCID

Affiliation:

1. Chongqing Research Center for Pharmaceutical Engineering

2. Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology

3. School of Pharmacy

4. Chongqing Medical University

5. Chongqing 400016

Abstract

Novel organocatalytic asymmetric cascade 1,6-addition/hemiketalization/retro-Henry reaction is developed to give new chiral 2-(1-(4-hydroxyphenyl)ethyl)phenols with good yields and excellent enantioselectivities under mild reaction conditions.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00397B

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