Molecular editing of <b>NSC-666719</b> enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents-Reference-Cited by-同舟云学术

Molecular editing of NSC-666719 enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents

Published:2024 Issue:3 Volume:15 Page:937-962
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Krishna Rao Vajja¹^ORCID,Paul Subarno²,Gulkis Mitchell³,Shen Zhihang⁴^ORCID,Nair Haritha⁵,Singh Amandeep⁶,Li Chenglong⁴,Sharma Arun K.⁶,Çağlayan Melike³,Das Chinmay²,Das Biswajit²,Kundu Chanakya N.²^ORCID,Narayan Satya⁵,Guchhait Sankar K.¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, SAS Nagar, Mohali, Punjab 160062, India

2. Cancer Biology Division, School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Campus-11, Patia, Bhubaneswar-751024, Odisha, India

3. Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, 1200 Newell Drive, Gainesville, FL 32610, USA

4. Department of Medicinal Chemistry, College of Pharmacy, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA

5. Department of Anatomy and Cell Biology, College of Medicine, University of Florida, 1200 Newell Drive, Gainesville, FL 32610, USA

6. Department of Pharmacology, Penn State Cancer Institute, CH72, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA

Abstract

In this study, a unique strategy of scaffold-hopping-based molecular editing of a bioactive agent NSC-666719 was investigated, which led to the development of new benzodithiazinedioxide-guanidine based anticancer agents with Polβ inhibition.

Funder

Science and Engineering Research Board

Council of Scientific and Industrial Research, India

Cancer Center, University of Florida Health

Department of Biotechnology, Ministry of Science and Technology, India

Indian Council of Medical Research

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00648D

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