Mutational biosynthesis to generate novel analogs of nosiheptide featuring a fluorinated indolic acid moiety-Reference-Cited by-同舟云学术

Mutational biosynthesis to generate novel analogs of nosiheptide featuring a fluorinated indolic acid moiety

Published:2020 Issue:21 Volume:18 Page:4051-4055
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhang E¹²³⁴,Guo Heng⁵⁶⁷⁸⁹,Chen Dandan⁵⁶⁷⁸⁹,Yang Qian⁵⁶⁷⁸⁹^ORCID,Fan Yafei¹²³⁴,Yin Yu¹⁰¹¹¹²⁴,Wang Wengui¹²³⁴¹³^ORCID,Chen Daijie¹⁰¹¹¹²⁴,Wang Shoufeng¹²³⁴¹³^ORCID,Liu Wen⁵⁶⁷⁸⁹

Affiliation:

1. School of Chemistry and Chemical Engineering

2. University of Jinan

3. Jinan

4. China

5. State Key Laboratory of Bioorganic and Natural Products Chemistry

6. Center for Excellence on Molecular Synthesis

7. Shanghai Institute of Organic Chemistry

8. University of Chinese Academy of Sciences

9. Shanghai 200032

10. School of Pharmacy

11. Shanghai Jiaotong University

12. Shanghai 200240

13. Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical materials

Abstract

The target product 6′-fluoro-nosiheptide (6′-F-NOS), along with 6′-fluoro-nosiheptide intermediate (NOS 6′-F-NOSint), was obtained by mutational biosynthesis via 6′-fluoro-MIA feeding into mutant NosL.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Chinese Academy of Sciences

Science and Technology Commission of Shanghai Municipality

Youth Innovation Promotion Association of the Chinese Academy of Sciences

K. C. Wong Education Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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