A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

Published:2018 Issue:75 Volume:54 Page:10630-10633
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ho Louisa A.¹²³⁴,Winogrodzki Judith L.⁵⁶⁷⁸,Debowski Aleksandra W.¹²³⁴⁹^ORCID,Madden Zarina¹⁰¹¹¹²⁸,Vocadlo David J.¹⁰¹¹¹²⁸^ORCID,Mark Brian L.⁵⁶⁷⁸^ORCID,Stubbs Keith A.¹²³⁴^ORCID

Affiliation:

1. School of Molecular Sciences

2. University of Western Australia

3. Crawley

4. Australia

5. Department of Microbiology

6. University of Manitoba

7. Winnipeg

8. Canada

9. School of Biomedical Sciences

10. Department of Chemistry

11. Simon Fraser University

12. Burnaby

Abstract

The development of a potent mechanism-based inactivator of NagZ, an enzyme critical to the production of inducible AmpC β-lactamase in Gram-negative bacteria, is presented.

Funder

Cystic Fibrosis Canada

Canadian Institutes of Health Research

Canada Research Chairs

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC05281F

Reference48 articles.

1. Centers for Disease Control and Prevention, Antibiotic resistance threats in the United States, 2013, US Department of Health and Human Services, pp. 1–114

2. World Health Organization, Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics, 2017, World Health Organization, Geneva, pp. 1–7

3. β-Lactams

4. Bench-to-bedside review: The role of β-lactamases in antibiotic-resistant Gram-negative infections

5. AmpC β-Lactamases

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3. Cefazolin and imipenem enhance AmpC expression and resistance in NagZ-dependent manner in Enterobacter cloacae complex;BMC Microbiology;2022-11-29

4. Elevating NagZ Improves Resistance to β-Lactam Antibiotics via Promoting AmpC β-Lactamase in Enterobacter cloacae;Frontiers in Microbiology;2020-11-04

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