Glycosaminoglycans are potential pharmacological targets for classic DNA minor groove binder drugs berenil and pentamidine-Reference-Cited by-同舟云学术

Glycosaminoglycans are potential pharmacological targets for classic DNA minor groove binder drugs berenil and pentamidine

Published:2015 Issue:38 Volume:17 Page:24560-24565
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Zsila Ferenc¹²³⁴⁵

Affiliation:

1. Research Group of Chemical Biology

2. Institute of Organic Chemistry

3. Research Centre for Natural Sciences

4. Hungarian Academy of Sciences

5. Budapest

Abstract

It is shown that the antiprotozoal drugs berenil and pentamidine, conventional minor groove binders of DNA, form non-covalent complexes with polyanionic glycosaminoglycans.

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CP/C5CP03153B

Reference23 articles.

1. Antiparasitic activity of aromatic diamidines and their patented literature

2. Pentamidine: A Review

3. Pharmacology of diminazene: a review

4. Berenil [1,3-Bis(4'-amidinophenyl)triazene] Binding to DNA Duplexes and to a RNA Duplex: Evidence for Both Intercalative and Minor Groove Binding Properties

5. NMR and molecular modeling studies of the interaction of berenil and pentamidine with d(CGCAAATTTGCG)2

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