A light-responsive, self-immolative linker for controlled drug delivery via peptide- and protein-drug conjugates-Reference-Cited by-同舟云学术

A light-responsive, self-immolative linker for controlled drug delivery via peptide- and protein-drug conjugates

Published:2019 Issue:39 Volume:10 Page:8973-8980
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zang Chuanlong¹²³⁴⁵,Wang Huawei¹²³⁴⁵,Li Tiantian⁶⁷⁸⁹,Zhang Yingqian¹²³⁴⁵,Li Jiahui¹²³⁴⁵,Shang Mengdi¹²³⁴⁵,Du Juanjuan⁶⁷⁸⁹,Xi Zhen¹²³⁴⁵,Zhou Chuanzheng¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Elemento-Organic Chemistry

2. Department of Chemical Biology

3. College of Chemistry

4. Nankai University

5. Tianjin 300071

6. School of Pharmaceutical Sciences

7. Tsinghua University

8. Beijing 100084

9. China

Abstract

Photoirradiation of the PC4AP linker generates an active intermediate that reacts intramolecularly with a primary amine on the carrier peptide/protein, leading to rapid release of the drug without generating any toxic side products.

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC03016F

Reference45 articles.

1. The expanding role of prodrugs in contemporary drug design and development