Design, synthesis, antifungal evaluation, and molecular docking of novel 1,2,4-triazole derivatives containing oxime ether and cyclopropyl moieties as potential sterol demethylase inhibitors-Reference-Cited by-同舟云学术

Design, synthesis, antifungal evaluation, and molecular docking of novel 1,2,4-triazole derivatives containing oxime ether and cyclopropyl moieties as potential sterol demethylase inhibitors

Published:2021 Issue:40 Volume:45 Page:18898-18907
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Sun Sheng-Xin¹,Yan Jing-Hua¹,Zuo Jiang-Tao¹,Wang Xiao-Bin¹,Chen Min¹²,Lu Ai-Min¹,Yang Chun-Long¹²^ORCID,Li Guo-Hua¹

Affiliation:

1. Jiangsu Key Laboratory of Pesticide Science, Nanjing Agricultural University, Nanjing, 210095, P. R. China

2. Department of Chemistry, College of Sciences, Nanjing Agricultural University, Nanjing, 210095, P. R. China

Abstract

A series of novel triazole derivatives containing oxime ether and cyclopropyl moieties were designed and synthesized. Some compounds exhibited remarkable antifungal activities. The molecular docking of compound 5k with FgCYP51 was investigated.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ03578A

Reference48 articles.

1. Novel 5-chloro-pyrazole derivatives containing a phenylhydrazone moiety as potent antifungal agents: synthesis, crystal structure, biological evaluation and a 3D-QSAR study

2. Design, synthesis, antifungal activity and 3D-QSAR study of novel pyrazole carboxamide and niacinamide derivatives containing benzimidazole moiety