Discovery of 4-benzoylpiperidine and 3-(piperidin-4-yl)benzo[d]isoxazole derivatives as potential and selective GlyT1 inhibitors-Reference-Cited by-同舟云学术

Discovery of 4-benzoylpiperidine and 3-(piperidin-4-yl)benzo[d]isoxazole derivatives as potential and selective GlyT1 inhibitors

Published:2015 Issue:51 Volume:5 Page:40964-40977
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Liu Yang¹²³⁴⁵,Guo Lin⁶⁷⁸⁵,Duan Hongliang¹²³⁴⁵,Zhang Liming¹²³⁴⁵,Jiang Neng⁹¹⁰⁵,Zhen Xuechu⁶⁷⁸⁵,Shen Jianhua¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Drug Research

2. Shanghai Institute of Materia Medica

3. Chinese Academy of Sciences

4. Shanghai 201203

5. China

6. Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and Department of Pharmacology

7. Soochow University

8. Suzhou 215006

9. China Pharmaceutical University

10. Nanjing 210009

Abstract

Two series of potential and selective GlyT1 inhibitors were discovered by bioisosteric replacement.23qwas effective on chronic PCP-treated schizophrenia-like behavioral models.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA04714E

Reference24 articles.

1. J. T. Coyle , D.Balu, M.Benneyworth, A.Basu and A.Roseman, Dialogues in Clinical Neuroscience, 2010, vol. 12, pp. 359–382

2. J. Kantrowitz and D. C.Javitt, Current Opinion in Psychiatry, 2012, vol. 25, pp. 96–102

3. Emerging Opportunities for Antipsychotic Drug Discovery in the Postgenomic Era

4. Glycine Transporter 1 Inhibitors and Modulation of NMDA Receptor-Mediated Excitatory Neurotransmission

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Benzoylpiperidine Fragment as a Privileged Structure in Medicinal Chemistry: A Comprehensive Review;Molecules;2024-04-23

2. The Isoxazole Ring and ItsN-Oxide: A Privileged Core Structure in Neuropsychiatric Therapeutics;ChemMedChem;2017-03-02

3. Privileged Structures and Motifs (Synthetic and Natural Scaffolds);Comprehensive Medicinal Chemistry III;2017

4. Unlocking the molecular mechanisms of antipsychotics – a new frontier for discovery;Swiss Medical Weekly;2016-07-11

5. A Highly Selective Inhibitor of Glycine Transporter-1 Elevates the Threshold for Maximal Electroshock-Induced Tonic Seizure in Mice;Biological & Pharmaceutical Bulletin;2016