Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicity<i>in vivo</i>-Reference-Cited by-同舟云学术

Platinum(terpyridine) complexes with N-heterocyclic carbene co-ligands: high antiproliferative activity and low toxicityin vivo

Published:2023 Issue:5 Volume:52 Page:1388-1392
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Sullivan Matthew P.¹²^ORCID,Adams Muneebah¹,Riisom Mie¹^ORCID,Herbert Caitlin D.³,Tong Kelvin K. H.¹,Astin Jonathan W.³,Jamieson Stephen M. F.⁴^ORCID,Hanif Muhammad¹^ORCID,Goldstone David C.²^ORCID,Hartinger Christian G.¹^ORCID

Affiliation:

1. School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

2. School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

3. Department of Molecular Medicine and Pathology, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

4. Auckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

Abstract

Substitution of a labile Cl−for an NHC ligand in DNA-intercalating [Pt(terpyridine)]+complexes improved the cytotoxicity and cellular accumulation, whilein vivostudies indicated good tolerability in zebrafish.

Funder

National Research Foundation

Health Research Council of New Zealand

University of Auckland

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/DT/D2DT02539F

Reference39 articles.

1. The resurgence of platinum-based cancer chemotherapy