Cardamonin targets KEAP1/NRF2 signaling for protection against atherosclerosis-Reference-Cited by-同舟云学术

Cardamonin targets KEAP1/NRF2 signaling for protection against atherosclerosis

Published:2023 Issue:10 Volume:14 Page:4905-4920
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Fan Pengfei¹²,Meng Huali¹²,Hao Wenhao¹²,Zheng Yan²,Li Hui³,Zhang Zhiyue³^ORCID,Du Lei¹²^ORCID,Guo Xin¹²,Wang Dongliang⁴^ORCID,Wang Yunyan⁵,Wu Hao¹²^ORCID

Affiliation:

1. Department of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 Wenhuaxi Rd., Jinan, Shandong 250012, China

2. Research Center of Translational Medicine, Jinan Central Hospital, Shandong University, 105 Jiefang Rd., Jinan, Shandong 250013, China

3. NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Wenhuaxi Rd., Jinan, Shandong 250012, China

4. Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), 74 Zhongshan Road II, Guangzhou 510080, China

5. Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, 107 Wenhuaxi Rd., Jinan, Shandong 250012, China

Abstract

Cardamonin and the Kelch domain inhibitor Ki696 structurally inhibit KEAP1, leading to the dissociation of NRF2 from KEAP1. This promotes NRF2 nuclear translocation and antioxidant gene expression, preventing atherosclerosis.

Funder

Natural Science Foundation of Shandong Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D3FO00967J

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