Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria

Author:

Jia Yuexiao1,Zhang Jiangjiang1,Zhao Yingcan1,Dong Ruihua1ORCID,Wang Hui2,Jiang Xingyu1ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of Advanced Biomaterials, Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088, Xueyuan Rd., Xili, Nanshan District, Shenzhen, Guangdong, 518055, P. R. China

2. Department of Clinical Laboratory, Peking University People's Hospital, Beijing 100044, P. R. China

Abstract

We introduce a clinically used non-antibiotic drug, N-acetyl-l-cysteine (NAC), to the synthesis of a new antimicrobial (Au_NAC) against multi-drug resistant Gram-negative bacteria by presenting it on gold nanoparticles (Au NPs).

Funder

Chinese Academy of Sciences

China Postdoctoral Science Foundation

National Natural Science Foundation of China

National Key R&D Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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