Dual inhibitory potential of ganoderic acid A on GLUT1/3: computational and in vitro insights into targeting glucose metabolism in human lung cancer

Author:

Bashir Mona Alrasheed123ORCID,Abdalla Mohnad45ORCID,Shao Chang-Sheng12,Wang Han12,Bondzie-Quaye Precious12ORCID,Almahi Waleed Abdelbagi6,Swallah Mohammed Sharif12ORCID,Huang Qing12ORCID

Affiliation:

1. CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China

2. Science Island Branch of Graduate School, University of Science and Technology of China, Hefei 230026, China

3. Department of Biotechnology, Faculty of Science and Technology, Omdurman Islamic University, P.O. Box 382, Omdurman, Sudan

4. Pediatric Research Institute, Children's Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China

5. Shandong Provincial Clinical Research Center for Children's Health and Disease, Jinan, Shandong 250022, China

6. Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China

Abstract

Human glucose transporters (GLUTs) facilitate the uptake of hexoses into cells. In cancer, the increased proliferation necessitates higher expression of GLUTs. This study demonstrates the inhibitory function of ganoderic acid A (GAA) on GLUT1/3.

Funder

National Natural Science Foundation of China

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

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