A protecting group free and scalable approach towards total synthesis of (−)-venlafaxine-Reference-Cited by-同舟云学术

A protecting group free and scalable approach towards total synthesis of (−)-venlafaxine

Published:2014 Issue:28 Volume:4 Page:14468-14470
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Chavan Subhash P.¹²³,Pawar Kailash P.¹²³,Garai Sumanta¹²³

Affiliation:

1. Division of Organic Chemistry

2. CSIR-NCL (National Chemical Laboratory)

3. Pune-411008, India

Abstract

A protecting group free asymmetric total synthesis of (−)-venlafaxine is reported. The strategy employs Sharpless epoxidation and regio-selective epoxide ring opening by an in situ generated Gilman reagent as key steps. This paper reports a 53% overall yield in 6 steps for total synthesis of (−)-venlafaxine.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA00840E

Reference16 articles.

1. Antidepressant efficacy of venlafaxine

2. 2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity

3. Pharmacotherapeutic profile of venlafaxine

4. An efficient and green protocol for the preparation of cycloalkanols: a practical synthesis of venlafaxine

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