A facile chemoselective deprotection of aryl silyl ethers using sodium hydride/DMF and in situ protection of phenol with various groups-Reference-Cited by-同舟云学术

A facile chemoselective deprotection of aryl silyl ethers using sodium hydride/DMF and in situ protection of phenol with various groups

Published:2014 Issue:32 Volume:4 Page:16438-16443
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Fernandes Rodney A.¹²³,Gholap Sachin P.¹²³,Mulay Sandip V.¹²³

Affiliation:

1. Department of Chemistry

2. Indian Institute of Technology Bombay

3. Mumbai 400 076, India

Abstract

A facile method for chemoselective aryl silyl ether deprotection with NaH/DMF is developed and a one-pot desilylation/reprotection as different aryl silyl ethers/esters has also been realized.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA00842A

Reference28 articles.

1. P. G. M. Wuts and T. W.Greene , Green's Protective Groups in Organic Synthesis , 4 th edn, John Wiley & Sons , Hoboken, NJ , 2007

2. P. J. Kocienski , Protecting Groups , Georg Thieme Verlag , Stuttgart , 1994

3. Selective monodeprotection of bis-silyl ethers

4. Selective deprotection of silyl ethers

5. Protection of hydroxyl groups as tert-butyldimethylsilyl derivatives

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