Umbelliferyloxymethyl phosphonate compounds-weakly binding zinc ionophores with neuroprotective properties-Reference-Cited by-同舟云学术

Umbelliferyloxymethyl phosphonate compounds-weakly binding zinc ionophores with neuroprotective properties

Published:2021 Issue:46 Volume:50 Page:17041-17051
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Guesne Sebastien¹,Connole Laura²,Kim Stephanie¹,Motevalli Majid¹,Robson Lesley²,Michael-Titus Adina T.²,Sullivan Alice¹^ORCID

Affiliation:

1. Dept. of Chemistry, Queen Mary University of London, Mile End Road, London E1 4NS, UK

2. Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, Mile End Road, London E1 4NS, UK

Abstract

Umbelliferyloxymethyl phosphonates:non-chelating ionophores that A protect rat hippocampal cells from toxic Aβ42 B partition Zn from water to octanol C inhibit Zn promoted aggregation of Aβ42, D delay Zn signaling by FluoZin-3 in neuronal cells.

Funder

Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/DT/D1DT02298A

Reference30 articles.

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4. Design, synthesis and biological evaluation of novel coumarin- N -benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease

5. Scopoletin: Antiamyloidogenic, Anticholinesterase, and Neuroprotective Potential of a Natural Compound Present in Argyreia speciosa Roots by In Vitro and In Silico Study

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