Non-terminal conjugation of small interfering RNAs with spermine improves duplex binding and serum stability with position-specific incorporation-Reference-Cited by-同舟云学术

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Non-terminal conjugation of small interfering RNAs with spermine improves duplex binding and serum stability with position-specific incorporation

Published:2023 Issue:36 Volume:13 Page:25169-25181
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Koyasu Keisuke¹,Chandela Akash²,Ueno Yoshihito¹²³

Affiliation:

1. Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, Japan

2. Course of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Japan

3. United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan

Abstract

This study for the very first time investigates non-terminal conjugation of spermine into small interfering RNAs exhibiting enhanced thermal stability and nuclease resistance, depending on the conjugation site.

Funder

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA04918C

Reference37 articles.

1. siRNA technology

2. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

3. RNA-triggered gene silencing

4. RNA interference—2001

5. Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

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