Synthesis and antiproliferative activities of OSW-1 analogues bearing 2-acylamino-xylose residues

Author:

Sun Lijun12345ORCID,Wang Ruina678910,Wang Xiaobo678910,Dang Yongjun678910ORCID,Li Wei511121314ORCID,Yu Biao511121314ORCID

Affiliation:

1. Department of Chemistry

2. University of Science and Technology of China

3. Hefei

4. China

5. State Key Laboratory of Bio-organic and Natural Products Chemistry

6. Key Laboratory of Metabolism and Molecular Medicine

7. the Ministry of Education

8. Department of Biochemistry and Molecular Biology

9. School of Basic Medical Sciences

10. Fudan University

11. Center for Excellence in Molecular Synthesis

12. Shanghai Institute of Organic Chemistry

13. Chinese Academy of Sciences

14. Shanghai 200032

Abstract

We synthesized 38 OSW-1 analogues with 2-acylamino xylose residues and found that the antitumor activities could be greatly enhanced.

Funder

National Natural Science Foundation of China

E-Institutes of Shanghai Municipal Education Commission

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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