Highly regio- and diastereoselective [3 + 2]-cycloadditions involving indolediones and α,β-disubstituted nitroethylenes

Author:

Rao Madhuri P.1234,Gunaga Shubha S.5674,Zuegg Johannes89101112ORCID,Pamarthi Rambabu1234,Ganesh Madhu1234ORCID

Affiliation:

1. Department of Chemistry

2. B.M.S College of Engineering

3. Bengaluru 560019

4. India

5. Solid State & Structural Chemistry Unit

6. Indian Institute of Science

7. Bengaluru 560012

8. CO-ADD

9. Institute for Molecular Bioscience

10. University of Queensland

11. Brisbane 4072

12. Australia

Abstract

Diastereoselective [3 + 2]-cycloadditions of oxindoles with α,β-disubstituted nitroethylenes: regioreversed spiropyrrolidines show potent MRSA activity.

Funder

Indian Institute of Technology Bombay

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference77 articles.

1. J. Bergmann , Oxindoles , in Advances in heterocyclic chemistry , ed. E. F. V. Scriven and C. A. Ramsden , Academic Press , Waltham, M. A. , 2015 , vol. 117 , pp. 1–81

2. S. A. Babu , R.Padmavathi , N. A.Aslam and V.Rajkumar , in Studies in Natural Products Chemistry , ed. Atta-ur-Rahman , Elsevier , Amsterdam , 1st edn, 2015 , vol. 46 , ch. 8, pp. 227–339

3. Therapeutic Potential of Spirooxindoles as Antiviral Agents

4. Review of synthesis and various biological activities of spiro heterocyclic compounds comprising oxindole and pyrrolidine moities

5. Spirooxindoles: Promising scaffolds for anticancer agents

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