Phloretin attenuation of hepatic steatosis via an improvement of mitochondrial dysfunction by activating AMPK-dependent signaling pathways in C57BL/6J mice and HepG2 cells-Reference-Cited by-同舟云学术

Phloretin attenuation of hepatic steatosis via an improvement of mitochondrial dysfunction by activating AMPK-dependent signaling pathways in C57BL/6J mice and HepG2 cells

Published:2021 Issue:24 Volume:12 Page:12421-12433
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Han Lin¹²^ORCID,Zhang Yao¹,Li Jia¹,Xiao Yao¹,Lu Mei³,Li Yunlong⁴,Wang Min¹^ORCID

Affiliation:

1. College of Food Science and Engineering, Northwest A&F University, Yangling 712100, P. R. China

2. Engineering Technology Research Center of Characteristic Biological Resources in Northeast of Chongqing, Chongqing Three Gorges University, Chongqing 404100, P. R. China

3. Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, USA

4. Institute of Functional Food of Shanxi, Shanxi Agricultural University, Taiyuan, P. R. China

Abstract

Phloretin significantly decreases HFD- or PA-induced hepatic steatosis, which is closely related to the promotion of mitochondrial biosynthesis and inhibition of mitochondrial swelling through the AMPK-dependent SIRT1/PGC-1α and SIRT3/CypD pathways.

Funder

National Natural Science Foundation of China

Northwest A and F University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FO/D1FO02577E

Reference41 articles.

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