Assessment of a bifendate derivative bearing a 6,7-dihydro-dibenzo[c,e]azepine scaffold as a potential anti-metastatic agent
Author:
Affiliation:
1. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy
2. Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy
3. Xuzhou Medical University
4. Xuzhou 221004
5. People's Republic of China
Abstract
4i exhibited significant anti-metastatic activity in MDA-MB-231 cells via inhibiting MMP-2/9 activity and expression.
Funder
Natural Science Foundation of Jiangsu Province
National Natural Science Foundation of China
Six Talent Peaks Project in Jiangsu Province
Publisher
Royal Society of Chemistry (RSC)
Subject
Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/MD/C8MD00294K
Reference27 articles.
1. The therapeutic potential of targeting ABC transporters to combat multi-drug resistance
2. Cancer chemoresistance; biochemical and molecular aspects: a brief overview
3. Potent Inhibition of Nitric Oxide-Releasing Bifendate Derivatives against Drug-Resistant K562/A02 Cells in Vitro and in Vivo
4. ABC transporters as mediators of drug resistance and contributors to cancer cell biology
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