Trisulfide linked cholesteryl PEG conjugate attenuates intracellular ROS and collagen-1 production in a breast cancer co-culture model-Reference-Cited by-同舟云学术

Trisulfide linked cholesteryl PEG conjugate attenuates intracellular ROS and collagen-1 production in a breast cancer co-culture model

Published:2021 Issue:3 Volume:9 Page:835-846
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Dao Nam V.¹²³⁴⁵,Ercole Francesca¹²³⁴⁵,Urquhart Matthew C.¹²³⁴⁵,Kaminskas Lisa M.⁶⁷⁸⁹,Nowell Cameron J.¹⁰⁴⁵¹¹⁹,Davis Thomas P.¹²³⁴⁵^ORCID,Sloan Erica K.¹⁰⁴⁵¹¹⁹,Whittaker Michael R.¹²³⁴⁵^ORCID,Quinn John F.¹²³⁴⁵^ORCID

Affiliation:

1. Australian Research Council - Centre of Excellence in Convergent Bio-Nano Science and Technology

2. Drug Delivery

3. Disposition and Dynamics Theme

4. Monash Institute of Pharmaceutical Sciences

5. Monash University

6. School of Biomedical Sciences

7. The University of Queensland

8. St Lucia

9. Australia

10. Drug Discovery Biology

11. Parkville

Abstract

Treatment of cancer cell-fibroblast co-cultures with H₂S-releasing trisulfide conjugate causes restoration of ROS levels in the cancer cells and normalisation of collagen-1 expression in the fibroblasts.

Funder

Australian Research Council

National Health and Medical Research Council

National Breast Cancer Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D0BM01544J

Reference87 articles.

1. Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles