Development of a triazinedione-based dehydrative condensing reagent containing 4-(dimethylamino)pyridine as an acyl transfer catalyst

Author:

Liu Jie12345,Fujita Hikaru12345ORCID,Kitamura Masanori1678,Shimada Daichi12345,Kunishima Munetaka12345ORCID

Affiliation:

1. Faculty of Pharmaceutical Sciences

2. Institute of Medical

3. Pharmaceutical

4. and Health Sciences

5. Kanazawa University

6. Matsuyama University

7. Matsuyama 790-8578

8. Japan

Abstract

Combination of the triazinedione core and 4-(dimethylamino)pyridine (DMAP) produced a powerful dehydrative condensing reagent for operationally simple esterification and amidation.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference32 articles.

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4. Ester coupling reactions – an enduring challenge in the chemical synthesis of bioactive natural products

5. K.Matsumoto , R.Yanagi and Y.Oe , in Carboxylic Acid - Key Role in Life Sciences , ed. G.-I. Badea and G. L. Radu , IntechOpen , Rijeka , 2018 , ch. 2

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