Rapid ‘on-column’ preparation of hydrogen [11C]cyanide from [11C]methyl iodide via [11C]formaldehyde-Reference-Cited by-同舟云学术

Rapid ‘on-column’ preparation of hydrogen [¹¹C]cyanide from [¹¹C]methyl iodide via [¹¹C]formaldehyde

Published:2022 Issue:12 Volume:13 Page:3556-3562
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Kikuchi Tatsuya¹^ORCID,Ogawa Masanao¹²,Okamura Toshimitsu¹,Gee Antony D.³^ORCID,Zhang Ming-Rong¹^ORCID

Affiliation:

1. Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan

2. SHI Accelerator Service, Ltd., 1-17-6 Osaki, Shinagawa-ku, Tokyo 141-0032, Japan

3. School of Biomedical Engineering and Imaging Sciences, King's College London, 4th Floor Lambeth Wing, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK

Abstract

In a reaction column, gaseous [11C]methyl iodide was converted to [11C]formaldehyde in a first layer containing N-oxide and then transformed into hydrogen [11C]cyanide in a second layer containing hydroxylamine-O-sulfonic acid within 2 minutes.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D1SC07033A

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