Simple and effective purification of a SGLT-2 inhibitor cocrystal Rongliflozin l-pyroglutamic acid: coformer-induced purification-Reference-Cited by-同舟云学术

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Simple and effective purification of a SGLT-2 inhibitor cocrystal Rongliflozin l-pyroglutamic acid: coformer-induced purification

Published:2021 Issue:46 Volume:23 Page:8033-8037
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Chen Dao-Qian¹²^ORCID,Gu Zheng¹²,Wu Yu-Sheng¹²,Yuan Wei-Hui¹²,Li Zheng¹²

Affiliation:

1. State Key Laboratory of Anti-Infective Drug Development, Sunshine Lake Pharma Co., Ltd, Dongguan 523871, P. R. China

2. HEC Pharm Group, HEC Research and Development Center, Dongguan 523871, P. R. China

Abstract

We report and design a simple and robust process to obtain a single and pure crystalline form I (1) of the cocrystal, containing Rongliflozin (2) with l-pyroglutamic acid (l-PA), based on coformer-induced purification (CoIP).

Funder

Guangdong Province Introduction of Innovative R&D Team

Basic and Applied Basic Research Foundation of Guangdong Province

National Major Science and Technology Projects of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CE/D1CE01305J

Reference27 articles.

1. Cocrystal engineering of pharmaceutical solids: therapeutic potential and challenges

2. Co-crystallization and small molecule crystal form diversity: from pharmaceutical to materials applications

3. Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications

4. Pharmaceutical cocrystals: walking the talk

5. Pharmaceutical cocrystals: along the path to improved medicines

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