Design of polyazamacrocyclic Gd3+ theranostic agents combining magnetic resonance imaging and two-photon photodynamic therapy

Author:

Abad Galán Laura12345ORCID,Hamon Nadège678910,Nguyen Christophe1112131415,Molnár Enikő16171819,Kiss János1620212219ORCID,Mendy Jonathan678910,Hadj-Kaddour Kamel1112131415,Onofre Mélanie1112131415,Trencsényi György1623242519ORCID,Monnereau Cyrille12345ORCID,Beyler Maryline678910ORCID,Tircsó Gyula16171819ORCID,Gary-Bobo Magali1112131415ORCID,Maury Olivier12345ORCID,Tripier Raphaël678910ORCID

Affiliation:

1. Univ Lyon

2. ENS de Lyon

3. CNRS UMR 5182

4. Université Claude Bernard Lyon 1

5. Laboratoire de Chimie de l'ENS de Lyon

6. Univ Brest

7. UMR-CNRS 6521 CEMCA

8. UFR des Sciences et Techniques

9. Brest

10. France

11. IBMM

12. Univ Montpellier

13. CNRS

14. ENSCM

15. Montpellier

16. University of Debrecen

17. Faculty of Science and Technology

18. Department of Physical Chemistry

19. Hungary

20. Clinical Centre

21. Department of Medical Imaging

22. Radiology

23. Faculty of Medicine

24. Medical Imaging Department

25. Division of Nuclear Medicine

Abstract

New “all-in-one” theranostic systems, combining a magnetic resonance imaging contrast agent with a biphotonic photodynamic therapy photosensitiser generating cytotoxic singlet oxygen, were successfully developed and characterized.

Funder

Agence Nationale de la Recherche

National Research, Development and Innovation Office

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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