Biomimetic synthesis of galantamine via laccase/TEMPO mediated oxidative coupling
Author:
Affiliation:
1. Department of Ecological and Biological Sciences
2. University of Tuscia
3. Viterbo
4. Italy
5. Department of Biotechnology, Chemistry and Pharmacy
6. University of Siena
7. 53100 Siena
Abstract
Laccase-mediated intramolecular oxidative radical coupling of N-formyl-2-bromo-O-methylnorbelladine afforded a novel and isolable spirocyclohexadienonic intermediate of galantamine.
Funder
Ministero dell'Istruzione, dell'Università e della Ricerca
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA00935K
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