Reshaping the active pocket of esterase Est816 for resolution of economically important racemates-Reference-Cited by-同舟云学术

Reshaping the active pocket of esterase Est816 for resolution of economically important racemates

Published:2021 Issue:18 Volume:11 Page:6126-6133
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Liu Xiaolong¹,Zhao Meng²,Fan Xinjiong²^ORCID,Fu Yao¹^ORCID

Affiliation:

1. Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, iChEM, University of Science and Technology of China, Hefei, Anhui 230026, China

2. School of Basic Medical Sciences, Anhui Medical University, 81 Meishan Rd, Hefei, 230032, Anhui, People's Republic of China

Abstract

Eight 2-arylpropionic acids with high E values were generated by engineered Est816, which overcomes the contradiction between the wide substrate scope and high enantioselectivity of esterases.

Funder

National Natural Science Foundation of China

Major Science and Technology Projects in Anhui Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CY/D1CY01028J

Reference32 articles.

1. Enantiomerically pure compounds related to chiral hydroxy acids derived from renewable resources

2. Biocatalytic strategies for the asymmetric synthesis of profens – recent trends and developments