Impact of RAFT chain transfer agents on the polymeric shell density of magneto-fluorescent nanoparticles and their cellular uptake

Author:

Blondy Thibaut1,Poly Julien2ORCID,Linot Camille1,Boucard Joanna13,Allard-Vannier Emilie4,Nedellec Steven5,Hulin Phillipe5,Hénoumont Céline6ORCID,Larbanoix Lionel7,Muller Robert N.6,Laurent Sophie67ORCID,Ishow Eléna3ORCID,Blanquart Christophe1ORCID

Affiliation:

1. Nantes Université, Inserm UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, F-44000 Nantes, France

2. IS2M-UMR CNRS 7361, Université de Haute Alsace, 15 rue Jean Starcky, 68057 Mulhouse, France

3. Nantes Université, CNRS, CEISAM, UMR 6230, F-44000 Nantes, France

4. EA 6295 ‘Nanomédicaments et Nanosondes’, Université de Tours, Tours, F-37200, France

5. Nantes Université, INSERM, UMS 016, CNRS, UMS 3556, F-44000 Nantes, France

6. Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons-Hainaut, B-7000 Mons, Belgium

7. Center for Microscopy and Molecular Imaging, 8 rue Adrienne Bolland à Gosselies, 6041 Gosselies, Belgium

Abstract

Nanoparticles coated with distinct comb-like RAFT pegylated polymers reveal differentiated cell uptake as a function of the PEG compaction that is ruled by the chemical nature of the incorporated RAFT chain transfer agents.

Funder

Agence Nationale de la Recherche

Conseil Régional des Pays de la Loire

Université de Nantes

Centre National de la Recherche Scientifique

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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