Atomic scale insights into urea–peptide interactions in solution-Reference-Cited by-同舟云学术

Atomic scale insights into urea–peptide interactions in solution

Published:2016 Issue:5 Volume:18 Page:3862-3870
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Steinke Nicola¹²³⁴,Gillams Richard J.¹²³⁴,Pardo Luis Carlos⁵⁶⁷⁸⁹,Lorenz Christian D.¹⁰¹¹¹²⁴,McLain Sylvia E.¹²³⁴^ORCID

Affiliation:

1. Department of Biochemistry

2. University of Oxford

3. Oxford OX1 3QU

4. UK

5. Departament de Física i Enginyeria Nuclear

6. Escola Tècnica Superior d'Enginyeria Industrial de Barcelona (ETSEIB)

7. Universitat Politècnica de Catalunya

8. 08028 Barcelona

9. Catalonia, Spain

10. Department of Physics

11. King's College London

12. London WC2R 2LS

Abstract

Investigations on the β-turn forming peptide, GPG, suggest that urea denatures proteins by replacing water molecules and subsequently weakening the peptide bonds as a possible mechanism of protein denaturation by urea.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CP/C5CP06646H

Reference55 articles.

1. Principles that Govern the Folding of Protein Chains

2. Effect of urea on the structural dynamics of water

3. Anatomy of energetic changes accompanying urea-induced protein denaturation

4. Backbone and Side-Chain Contributions in Protein Denaturation by Urea

5. Urea Impedes the Hydrophobic Collapse of Partially Unfolded Proteins

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