Synthesis and initial evaluation of radioactive 5-I-α-methyl-tryptophan: a Trp based agent targeting IDO-1-Reference-Cited by-同舟云学术

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Synthesis and initial evaluation of radioactive 5-I-α-methyl-tryptophan: a Trp based agent targeting IDO-1

Published:2019 Issue:5 Volume:10 Page:814-816
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Giglio Benjamin C.¹²³⁴,Wang Hui¹²³⁴,Yan Xuefeng¹²³⁴^ORCID,Li Zibo¹²³⁴^ORCID

Affiliation:

1. Department of Radiology and Biomedical Research Imaging Center

2. University of North Carolina at Chapel Hill

3. Chapel Hill

4. USA

Abstract

A synthetic approach is established to achieve radioactive 5-I-α-methyl-tryptophan (5-I-AMT).

Funder

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00082H

Reference16 articles.

1. LW106, a novel indoleamine 2,3‐dioxygenase 1 inhibitor, suppresses tumour progression by limiting stroma‐immune crosstalk and cancer stem cell enrichment in tumour micro‐environment

2. Modulating Tumor Immunology by Inhibiting Indoleamine 2,3-Dioxygenase (IDO): Recent Developments and First Clinical Experiences

3. Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer

4. Epacadostat plus pembrolizumab in patients with advanced melanoma and select solid tumors: Updated phase 1 results from ECHO-202/KEYNOTE-037

5. First-in-Human Phase I Study of the Oral Inhibitor of Indoleamine 2,3-Dioxygenase-1 Epacadostat (INCB024360) in Patients with Advanced Solid Malignancies

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1. Synthesis Principle and Practice with Radioactive Iodines and Astatine: Advances Made So Far;The Journal of Organic Chemistry;2024-08-22

2. Development of [¹⁸F]F-5-OMe-Tryptophans through Photoredox Radiofluorination: A New Method to Access Tryptophan-Based PET Agents;Journal of Medicinal Chemistry;2023-02-24

3. Recent Advances in Synthetic Methods for Radioiodination;The Journal of Organic Chemistry;2020-05-05

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