A polysaccharide extracted from alfalfa activates splenic B cells by TLR4 and acts primarily via the MAPK/p38 pathway-Reference-Cited by-同舟云学术

A polysaccharide extracted from alfalfa activates splenic B cells by TLR4 and acts primarily via the MAPK/p38 pathway

Published:2020 Issue:10 Volume:11 Page:9035-9047
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Xie Yuhuai¹²³⁴⁵,Wang Lixue¹²³⁴⁵,Sun Hua⁶⁷⁵,Shang Qinghui⁸⁹¹⁰⁵,Wang Yuxi¹¹¹²¹³¹⁴¹⁵,Zhang Guiguo¹²³⁴⁵,Yang Weiren¹²³⁴⁵^ORCID,Jiang Shuzhen¹²³⁴⁵

Affiliation:

1. Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention

2. College of Animal Science and Veterinary Medicine

3. Shandong Agricultural University

4. Tai'an

5. PR China

6. Qilu University of Technology (Shandong Academy of Sciences)

7. Jinan

8. Department of Animal Science and Technology

9. China Agricultural University

10. Beijing

11. Lethbridge Research Centre

12. Agriculture and Agri-Food C

13. Lethbridge

14. anada

15. Canada

Abstract

Alfalfa polysaccharide (APS) activates the immune functions of splenic B cells by TLR4, acting through the MAPK and NF-κB signaling pathways, and potently activates the p38 pathway.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/FO/D0FO01711F

Reference53 articles.

1. Stimulation and Suppression of Innate Immune Function by American Ginseng Polysaccharides: Biological Relevance and Identification of Bioactives

2. Activation of mouse macrophages and dendritic cells induced by polysaccharides from a novel Cordyceps sinensis fungus UM01

3. β-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1β Production

4. Toll-like receptor-mediated activation of B cells and macrophages by polysaccharide isolated from cell culture of Acanthopanax senticosus

5. Coriolus versicolor mushroom polysaccharides exert immunoregulatory effects on mouse B cells via membrane Ig and TLR-4 to activate the MAPK and NF-κB signaling pathways

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