All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery-Reference-Cited by-同舟云学术

All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery

Published:2020 Issue:12 Volume:8 Page:3270-3277
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Costa Clarinda¹²³⁴⁵^ORCID,Liu Zehua¹²³⁴⁵,Martins João P.¹²³⁴⁵,Correia Alexandra¹²³⁴⁵,Figueiredo Patrícia¹²³⁴⁵,Rahikkala Antti¹²³⁴⁵,Li Wei¹²³⁴⁵^ORCID,Seitsonen Jani⁶⁷⁸⁹,Ruokolainen Janne⁶⁷⁸⁹,Hirvonen Sami-Pekka¹⁰¹¹⁴⁵⁹,Aguiar-Ricardo Ana¹²¹³¹⁴¹⁵¹⁶^ORCID,Corvo M. Luísa¹⁷¹⁸¹⁹²⁰²¹,Santos Hélder A.¹²³⁴⁵^ORCID

Affiliation:

1. Drug Research Program

2. Division of Pharmaceutical Chemistry and Technology

3. Faculty of Pharmacy

4. University of Helsinki

5. Helsinki

6. Nanomicroscopy center

7. Aalto University

8. Aalto

9. Finland

10. Department of Chemistry

11. Faculty of Science

12. LAQV-REQUIMTE

13. Departamento de Química

14. Faculdade de Ciências e Tecnologia

15. Universidade Nova de Lisboa

16. 2829-516 Caparica

17. Instituto de Investigação do Medicamento (iMed.ULisboa)

18. Faculdade de Farmácia

19. Universidade de Lisboa

20. 1649-003 Lisboa

21. Portugal

Abstract

Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral insulin delivery system is reported. This system represents a promising alternative for the common protein/peptide-loaded liposome formulations.

Funder

Fundação para a Ciência e a Tecnologia

Sigrid Juséliuksen Säätiö

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/BM/D0BM00743A

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1. Challenges for the oral delivery of macromolecules

2. Layer-by-layer assembled milk protein coated magnetic nanoparticle enabled oral drug delivery with high stability in stomach and enzyme-responsive release in small intestine