Incorporation of ‘click’ chemistry glycomimetics dramatically alters triple-helix stability in an adiponectin model peptide-Reference-Cited by-同舟云学术

Incorporation of ‘click’ chemistry glycomimetics dramatically alters triple-helix stability in an adiponectin model peptide

Published:2017 Issue:26 Volume:15 Page:5602-5608
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Lutteroth Katherine R.¹²³⁴⁵,Harris Paul W. R.¹²³⁴⁵,Wright Tom H.¹²³⁴⁵^ORCID,Kaur Harveen¹²³⁴⁵,Sparrow Kevin¹²³⁴⁵,Yang Sung-Hyun¹²³⁴⁵,Cooper Garth J. S.⁵²³⁴⁶^ORCID,Brimble Margaret A.¹²³⁴⁵^ORCID

Affiliation:

1. School of Chemical Sciences

2. The University of Auckland

3. Auckland

4. New Zealand

5. Maurice Wilkins Centre for Molecular Biodiscovery

6. Centre for Advanced Discovery & Experimental Therapeutics (CADET)

Abstract

A striking decrease in thermal stability was observed upon incorporation of triazole-linked galactosylated-lysine into an adiponectin model peptide, suggesting possible applications of ‘click’ glycomimetics in bioengineering.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01388D

Reference54 articles.

1. Role of Adiponectin in the Metabolic Syndrome: Current Perspectives on its Modulation as a Treatment Strategy

2. Genetic Variation in the Gene Encoding Adiponectin Is Associated With an Increased Risk of Type 2 Diabetes in the Japanese Population

3. Fasting serum adiponectin concentration is reduced in Indo-Asian subjects and is related to HDL cholesterol

4. Low-molecular-weight adiponectin and high-molecular-weight adiponectin levels in relation to diabetes

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