Biomimetic and immunomodulatory baicalin-loaded graphene oxide-demineralized bone matrix scaffold for in vivo bone regeneration

Author:

Guo Bing1,Feng Xiaodong2,Wang Yun3,Wang Xiansong3ORCID,He Yue1ORCID

Affiliation:

1. Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center of Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China

2. Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266000, China

3. Department of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China

Abstract

A bifunctional GO–BAI/DBM scaffold with enhanced osteoinductive and immunomodulatory performance significantly enhanced material-mediated osteogenesis and angiogenesis via the coordinated involvement of macrophages and bone mesenchymal stem cells.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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