A transcriptome based approach to predict candidate drug targets and drugs for Parkinson's disease using an <i>in vitro</i> 6-OHDA model-Reference-Cited by-同舟云学术

A transcriptome based approach to predict candidate drug targets and drugs for Parkinson's disease using an in vitro 6-OHDA model

Published:2023 Issue:3 Volume:19 Page:218-228
ISSN:2515-4184
Container-title:Molecular Omics
language:en
Short-container-title:Mol. Omics

Author:

Yiğit Esra Nur¹²^ORCID,Sönmez Ekin¹^ORCID,Yüksel İsa³,Aksan Kurnaz Işıl¹⁴^ORCID,Çakır Tunahan³^ORCID

Affiliation:

1. Institute of Biotechnology, Gebze Technical University, 41400, Gebze, Kocaeli, Turkey

2. Research Institute for Health Sciences and Technologies (SABITA), İstanbul Medipol University, İstanbul, Turkey

3. Department of Bioengineering, Gebze Technical University, 41400, Gebze, Kocaeli, Turkey

4. Department of Molecular Biology and Genetics, Gebze Technical University, 41400, Gebze, Kocaeli, Turkey

Abstract

Transcriptomic data from an in vitro model is used to predict candidate drug targets for Parkinson’s disease, which are further validated using a drug repurposing approach.

Funder

Türkiye Bilimsel ve Teknolojik Araştirma Kurumu

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MO/D2MO00267A

Reference50 articles.

1. Genetics of Parkinson’s disease and related disorders

2. Parkinson’s Disease Drug Therapies in the Clinical Trial Pipeline: 2020

3. LRRK2 in Parkinson disease: challenges of clinical trials

4. Drug Repurposing for Parkinson’s Disease: The International Linked Clinical Trials experience

5. Drug repurposing strategies of relevance for Parkinson’s disease

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