Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase-Reference-Cited by-同舟云学术

Heterologous production of asperipin-2a: proposal for sequential oxidative macrocyclization by a fungi-specific DUF3328 oxidase

Published:2019 Issue:1 Volume:17 Page:39-43
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ye Ying¹²³⁴⁵,Ozaki Taro¹²³⁴⁵^ORCID,Umemura Myco⁶⁷⁸⁵⁹,Liu Chengwei¹²³⁴⁵,Minami Atsushi¹²³⁴⁵,Oikawa Hideaki¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Faculty of Science

3. Hokkaido University

4. Sapporo 060-0810

5. Japan

6. Bioproduction Research Institute

7. National Institute of Advanced Industrial Science and Technology (AIST)

8. Tsukuba 305-8566

9. Computational Bio Big Data Open Innovation Laboratory (CBBD-OIL)

Abstract

A heterologous production of asperipin-2a and determination of its absolute structure revealed a sequential oxidative cyclization catalyzed by DUF3328 oxidase.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02824A

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5. Characterization of the biosynthetic gene cluster for the ribosomally synthesized cyclic peptide ustiloxin B in Aspergillus flavus

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