The tug of war between Al3+ and Na+ for order–disorder transitions in lipid-A membranes-Reference-Cited by-同舟云学术

The tug of war between Al3+ and Na+ for order–disorder transitions in lipid-A membranes

Published:2021 Issue:28 Volume:23 Page:15127-15137
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Messias Andresa¹²³⁴,Santos Denys E. S.¹²³⁴,Pontes Frederico J. S.¹²³⁴,Soares Thereza A.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Fundamental Chemistry

2. Universidade Federal de Pernambuco

3. 50740-560 Recife

4. Brazil

5. Instituto de Fisica

Abstract

Lipid-A can exhibit antagonist/agonist immunomodulatory properties depending on its chemical compostion. Computational simulations provide insights into the role of Al³⁺ and Na⁺ cations on the physical properties of lipid-A aggregates, and guidance in the development of vaccine adjuvants capable of boosting the immune system with decreased reactogenicity.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D1CP02173G

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