Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau-Reference-Cited by-同舟云学术

Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau

Published:2019 Issue:26 Volume:10 Page:6503-6507
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Ambadipudi Susmitha¹²³,Reddy Jithender G.⁴⁵³⁶⁷,Biernat Jacek¹⁸³,Mandelkow Eckhard¹⁸³⁹¹⁰,Zweckstetter Markus¹²³⁴⁵^ORCID

Affiliation:

1. Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)

2. 37075 Göttingen

3. Germany

4. Max-Planck-Institut für Biophysikalische Chemie

5. 37077 Göttingen

6. NMR & Structural Chemistry Division

7. CSIR-Indian Institute of Chemical Technology

8. 53175 Bonn

9. CAESAR Research Center, Bonn

10. MPI for Metabolism Research

Abstract

Visualizing liquid–liquid phase separation by NMR spectroscopy: LLPS of the Alzheimer's-related protein tau involves aggregation-prone hexapeptides and activity regulating KXGS motifs.

Funder

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC00531E

Reference37 articles.

1. Phase separation in biology; functional organization of a higher order

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3. Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

4. Liquid–liquid phase separation in cellular signaling systems

5. Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

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