Scleral ossicles: angiogenic scaffolds, a novel biomaterial for regenerative medicine applications

Author:

Checchi Marta12345ORCID,Bertacchini Jessika12345ORCID,Cavani Francesco12345ORCID,Magarò Maria Sara12345ORCID,Reggiani Bonetti Luca6345ORCID,Pugliese Geltrude Rita12345ORCID,Tamma Roberto7891011ORCID,Ribatti Domenico7891011ORCID,Maurel Delphine B.1213141516ORCID,Palumbo Carla12345ORCID

Affiliation:

1. Department of Biomedical

2. Metabolic Science and Neuroscience

3. University of Modena and Reggio Emilia

4. 41125 Modena

5. Italy

6. Department of Pathology

7. Department of Basic Medical Sciences

8. Neurosciences and Sensory Organs

9. Section of Human Anatomy and Histology

10. University of Bari Medical School

11. 70124 Bari

12. Pharmaceutical Sciences Department

13. University of Bordeaux

14. Bio-Tis

15. INSERM Unit 1026

16. 33076 Bordeaux

Abstract

We tested a peculiar biomaterial, the scleral ossicle, for the induction of the angiogenic response, in vivo biocompatibility by subcutaneous implantation in the rat model and finally, we found some putative proteins involved in its angiogenic properties.

Funder

Università Degli Studi di Modena e Reggio Emila

Fondazione Cassa di Risparmio di Modena

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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