In silico research to assist the investigation of carboxamide derivatives as potent TRPV1 antagonists-Reference-Cited by-同舟云学术

In silico research to assist the investigation of carboxamide derivatives as potent TRPV1 antagonists

Published:2015 Issue:11 Volume:11 Page:2885-2899
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Wang Jinghui¹²³⁴⁵,Li Yan¹²³⁴⁵,Yang Yinfeng¹²³⁴⁵,Du Jian¹²³⁴⁵,Zhang Shuwei¹²³⁴⁵,Yang Ling⁶⁷⁸⁵⁹

Affiliation:

1. Key Laboratory of Industrial Ecology and Environmental Engineering (MOE)

2. Faculty of Chemical

3. Environmental and Biological Science and Technology

4. Dalian University of Technology

5. Dalian

6. Laboratory of Pharmaceutical Resource Discovery

7. Dalian Institute of Chemical Physics

8. Graduate School of the Chinese Academy of Sciences

9. China

Abstract

The transient receptor potential vanilloid type 1 (TRPV1), a non-selective cation channel, is known for its essential role in the pathogenesis of various pain conditions such as nerve damage induced hyperalgesia, diabetic neuropathy and cancer pain.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MB/C5MB00356C

Reference63 articles.

1. TRPV1 Antagonists as Potential Antitussive Agents

2. The capsaicin receptor: a heat-activated ion channel in the pain pathway

3. Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1

4. Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor

5. Retinal Cell Death Induced by TRPV1 Activation Involves NMDA Signaling and Upregulation of Nitric Oxide Synthases

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