Transdermal delivery of poly-hyaluronic acid-based spherical nucleic acids for chemogene therapy

Author:

Jiang Kai1,Zhao Di2,Ye Rui1,Liu Xinlong3,Gao Chao1,Guo Yuanyuan3,Zhang Chuan3ORCID,Zeng Jian4,Wang Shi4,Song Jie14ORCID

Affiliation:

1. Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, People's Republic of China

2. School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, People's Republic of China

3. School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, People's Republic of China

4. Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences; The Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, People's Republic of China

Abstract

PHAAD NPs, PHA-based spherical nucleic acids, represent a new transdermal delivery system for efficient combinatorial chemo and gene therapy for HS therapy.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shanghai

Shanghai Jiao Tong University

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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