Comparative binding analysis of WGX50 and Alpha-M with APP family proteins APLP1 and APLP2 using structural-dynamics and free energy calculation approaches

Author:

Ali Arif1ORCID,Masood Adan2,Khan Abdul Aziz3,Zhu Feng-Yun4,Cheema Muhammad Arslan Rasheed5,Samad Abdus6,Wadood Abdul6,Khan Abbas17ORCID,Yu Qiu8,Heng Wang9,Li Daixi107,Wei Dong-Qing111712ORCID

Affiliation:

1. Department of Bioinformatics and Biological Statistics, Shanghai Jiao Tong University, Shanghai, P. R. China

2. University Medical and Dental College, Faisalabad, Punjab, Pakistan

3. Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Institute of Psychology and Behavioral Sciences, Shanghai Jiao Tong University, Shanghai, China

4. College of Biology and Food Engineering, Huanghuai University, Zhumadian, 463000, Henan, China

5. DTC, District Officer Health, Gujranwala, Pakistan

6. Department of Biochemistry, Abdul Wali khan University Mardan, 23200 Khyber Pakhtunkhwa, Pakistan

7. Peng Cheng Laboratory, Vanke Cloud City Phase I Building 8, Xili Street, Nashan District, Shenzhen, Guangdong, 518055, P. R. China

8. Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

9. International School of Cosmetics, School of Perfume and Aroma Technology, Shanghai Institute of Technology, China

10. Institute of Biothermal Science and Technology, University of Shanghai for Science and Technology, Shanghai, 20093, China

11. State Key Laboratory of Microbial Metabolism, Shanghai-Islamabad-Belgrade Joint Innovation Center on Antibacterial Resistances, Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences, Ministry of Education and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, P. R. China

12. Zhongjing Research and Industrialization Institute of Chinese Medicine, Zhongguancun Scientific Park, Meixi, Nayang, Henan, 473006, P. R. China

Abstract

A.D. is a common disease among other neurodegenerative disorders primarily developing due to amyloid-β (Aβ) neurotoxicity derived from the amyloid-β protein precursor (AβPP).

Funder

Science and Technology Commission of Shanghai Municipality

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Natural Science Foundation of Henan Province

Shanghai Jiao Tong University

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3