Palladium/XuPhos-catalyzed enantioselective cascade Heck/intermolecular C(sp<sup>2</sup>)–H alkylation reaction-Reference-Cited by-同舟云学术

Palladium/XuPhos-catalyzed enantioselective cascade Heck/intermolecular C(sp²)–H alkylation reaction

Published:2024 Issue:15 Volume:15 Page:5573-5580
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Fang Chao¹,Wang Quan-Pu¹,Xu Bing¹²,Zhang Zhan-Ming¹³^ORCID,Zhang Junliang¹²⁴^ORCID

Affiliation:

1. Department of Chemistry, Fudan University, Shanghai, 200438, P. R. China

2. Zhuhai Fudan Innovation Institute, Zhuhai, Guangdong, 519000, P. R. China

3. Fudan Zhangjiang Institute, Shanghai, 201203, P. R. China

4. School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, P. R. China

Abstract

An asymmetric domino Heck/intermolecular C–H alkylation of unactivated alkenes with diverse polyfluoro- and heteroarenes in a highly chemo- and enantioselective manner was demonstrated, with the use of a Pd/XuPhos catalyst.

Funder

National Natural Science Foundation of China

Shanghai Municipal Education Commission

National Key Research and Development Program of China

China Postdoctoral Science Foundation

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC00262H

Reference35 articles.

1. Palladium(II)-Catalyzed CH Activation/CC Cross-Coupling Reactions: Versatility and Practicality

2. Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond Activation

3. Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions

4. Transition metal-catalyzed ketone-directed or mediated C–H functionalization

5. Mild metal-catalyzed C–H activation: examples and concepts

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