Folates are potential ligands for ruthenium compounds in vivo-Reference-Cited by-同舟云学术

Folates are potential ligands for ruthenium compounds in vivo

Published:2014 Issue:22 Volume:43 Page:8158-8161
ISSN:1477-9226
Container-title:Dalton Trans.
language:en
Short-container-title:Dalton Trans.

Author:

Scrase Tom G.¹²,Page Simon M.¹²,Barker Paul D.¹²,Boss Sally R.¹²

Affiliation:

1. The University of Cambridge Chemical Laboratory

2. Cambridge, UK

Abstract

A labile ruthenium(ii) complex has been observed to chelate to folates under physiologically relevant conditions. The diastereomeric complexes formed would interfere with the one-carbon carrying role of folate in vivo. This highlights the importance of considering small molecules alongside macromolecules when determining the chemical origins of cytotoxicity of metallodrug candidates.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/DT/C4DT00081A

Reference35 articles.

1. Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

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