A numerical study on drug delivery via multiscale synergy of cellular hitchhiking onto red blood cells-Reference-Cited by-同舟云学术

A numerical study on drug delivery via multiscale synergy of cellular hitchhiking onto red blood cells

Published:2021 Issue:41 Volume:13 Page:17359-17372
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Nikfar Mehdi¹^ORCID,Razizadeh Meghdad¹,Paul Ratul¹,Muzykantov Vladimir²,Liu Yaling¹³^ORCID

Affiliation:

1. Department of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, Pennsylvania 18015, USA

2. Department of Systems Pharmacology and Translational Therapeutics and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

3. Department of Bioengineering, Lehigh University, Bethlehem, Pennsylvania 18015, USA

Abstract

Red blood cell (RBC)-hitchhiking, in which different nanocarriers (NCs) shuttle on the erythrocyte membrane and disassociate from RBCs to the first organ downstream of the intravenous injection spot, has recently been introduced as a solution to enhance target site uptake.

Funder

National Institutes of Health

Center for Hierarchical Manufacturing, National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NR/D1NR04057J

Reference61 articles.

1. Nanoparticles in Cancer Treatment: Opportunities and Obstacles

2. Delivering Nanoparticles to Lungs while Avoiding Liver and Spleen through Adsorption on Red Blood Cells

3. Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier

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