Metabolic response to Parkinson's disease recapitulated by the haploinsufficient diploid yeast cells hemizygous for the adrenodoxin reductase gene-Reference-Cited by-同舟云学术

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Metabolic response to Parkinson's disease recapitulated by the haploinsufficient diploid yeast cells hemizygous for the adrenodoxin reductase gene

Published:2019 Issue:5 Volume:15 Page:340-347
ISSN:2515-4184
Container-title:Molecular Omics
language:en
Short-container-title:Mol. Omics

Author:

Dikicioglu Duygu¹²³⁴^ORCID,Coxon James W. M. T.⁵²⁴^ORCID,Oliver Stephen G.⁶²³⁴^ORCID

Affiliation:

1. Department of Chemical Engineering and Biotechnology

2. University of Cambridge

3. Cambridge

4. UK

5. Department of Pathology

6. Department of Biochemistry

Abstract

ARH1-impaired yeast reorganises iron assimilation and tyrosine biosynthesis, suggesting its potential as early-stage Parkinson's disease model, since patient metabolic responses implicate interconnection between these pathways.

Funder

Leverhulme Trust

Biotechnology and Biological Sciences Research Council

FP7 Food, Agriculture and Fisheries, Biotechnology

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MO/C9MO00090A

Reference71 articles.

1. Iron is essential for living!

2. A precious metal: Iron, an essential nutrient for all cells

3. Shared and distinct mechanisms of iron acquisition by bacterial and fungal pathogens of humans

4. Bacterial iron homeostasis

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