Serendipitous discovery of a novel polymorph of an immunosuppressant drug azathioprine: phase transformation, solubility, dissolution and stability study-Reference-Cited by-同舟云学术

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Serendipitous discovery of a novel polymorph of an immunosuppressant drug azathioprine: phase transformation, solubility, dissolution and stability study

Published:2024 Issue: Volume: Page:
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Kalavalapudi Likhitha¹,Palani Sivanarayanan¹²,Nechipadappu Sunil Kumar¹²^ORCID

Affiliation:

1. Centre for X-ray Crystallography, Department of Analytical & Structural Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India

2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India

Abstract

A novel polymorph of an immunosuppressant drug azathioprine (AZP) is prepared (F-III) along with two solvates (2-methoxyethanol (MEE) and 1,4-dioxane (DOX)) and a monohydrate of AZP.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CE/D4CE00589A

Reference46 articles.

1. J.Bernstein , Polymorphism in Molecular Crystals 2e , International Union of Crystal , 2020

2. Crystalline solids

3. Drug polymorphism and dosage form design: a practical perspective

4. Polymorph Impact on the Bioavailability and Stability of Poorly Soluble Drugs

5. Impact of polymorphism on mechanical properties of molecular crystals: a study of p-amino and p-nitro benzoic acid with nanoindentation

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