Rational design of a peptide capture agent for CXCL8 based on a model of the CXCL8:CXCR1 complex

Author:

Helmer Dorothea12345,Rink Ina1234,Dalton James A. R.678910,Brahm Kevin1234,Jöst Marina1234,Nargang Tobias M.511124,Blum Witali1234,Wadhwani Parvesh513144,Brenner-Weiss Gerald515124,Rapp Bastian E.511124,Giraldo Jesús678910,Schmitz Katja1234ORCID

Affiliation:

1. Technische Universität Darmstadt

2. Clemens-Schöpf-Institut

3. 64287 Darmstadt

4. Germany

5. Karlsruhe Institute of Technology

6. Laboratory of Molecular Neuropharmacology and Bioinformatics

7. Institut de Neurociències and Unitat de Bioestadística

8. Universitat Autònoma de Barcelona

9. 08193 Bellaterra

10. Spain

11. Institute of Microstructure Technology

12. 76344 Eggenstein-Leopoldshafen

13. Institute of Biological Interfaces (IBG-2)

14. 76021 Karlsruhe

15. Institute of Functional Interfaces

Abstract

A CXCL8-binding peptide designed from the interaction sites of CXCR1 with CXCL8 serves as a capture agent and inhibits neutrophil migration.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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